PTC Therapeutics, Inc.
Research Associate II, Biology (Biotech)
The Research Associate II, Biology supports adherence to all regulatory requirements and company Standard Operating Procedures (SOPs) including as appropriate.
ESSENTIAL FUNCTIONS
Primary duties/responsibilities:
Under general guidance, executes experiments and communicates results as part of multi-disciplinary team(s).
Applies relevant scientific principles and techniques to research problems.
Maintains detailed laboratory notebooks.
Maintains knowledge of state-of-the-art principles and techniques.
Ability to trouble shoot experiments -designing controls, generating interpretable data.
Presents findings internally and contributes to the publication of the work of the project team.
Contributes to the development of patent applications as appropriate.
Complies with all safety requirements.
Contributes to laboratory needs, such as stock room maintenance and ordering supplies.
Involved in general lab duties as assigned.
Specific duties may also include, but may not be limited to, the following:
Provides support for lead optimization by screening compounds and/or supporting structure activity relationship (SAR) studies involving the characterization of the biological activity of compounds in various assays. Profiles selected compounds in additional cells/assays.
Provides support for in vivo studies as required.
Assists in the development of biologically relevant alternatives to preclinical animal models.
Conducts mechanism of drug activity studies.
Provides support for the characterization of PTC compounds on different immune cells.
Culture and maintenance of cell lines
KNOWLEDGE/SKILLS/ABILITIES REQUIRED
* Minimum level of education and years of relevant work experience.
Bachelor's degree in a Biology scientific discipline with 3-5 years' relevant experience.
* Special knowledge or skills needed and/or licenses or certificates required.
Human/mouse tissue culture experience is required.
Knowledge of and ability to use standard cellular and immunology techniques (ELISA, ELISPOT etc).
Demonstrates technical proficiency, and the ability to collaborate with others on cross functional teams in a fast-paced, matrixed, environment consisting of internal and external team members.
Possesses knowledge of scientific principles and concepts and keeps current with relevant scientific literature.
Proficiency with Microsoft Office- preferably MS Excel and MS PowerPoint.
Effective verbal and written communication and skills.
Analytical thinker with problem-solving skills and the ability to adapt to changing priorities and deadlines.
Effective planning, organization and time management skills including the ability to support and prioritize multiple projects.
*Special knowledge or skills and/or licenses or certificates preferred.
Flow cytometry experience desired but not required.
Experience with animal models desired but not required.
Immunoassay experience – moderate to high-throughput assays for protein detection using different platforms.
Experience with mRNA expression profiling.
* Travel requirements
Up to 5%
**At PTC Therapeutics we are seeking candidates in the United States who are fully vaccinated against COVID-19 or who will be fully vaccinated by the time they begin the position.
EEO Statement:
PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.
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